Page 7 - The Use of Cannabis and Cannabinoids in Treating Symptoms of Multiple Sclerosis: a Systematic Review of Reviews

Curr Neurol Neurosci Rep (2018) 18:8 Page 7 of 12 8

Adverse events 2 studies (2 RCT) AEs > comparator Low quality Insufficient evidence 8 studies (6 RCT) AEs > comparator Very low to high quality Mild AEs likely 1 studies (1 RCT) AEs > comparator Low quality Mild AEs likely 10 studies (7 RCT) AEs > comparator Very low to moderate quality Mild AEs likely 8 studies (6 RCT) AEs > comparator Low to high quality Mild AEs likely 3 studies (3 RCT) AEs > comparator Very low to low quality

Quality of life 2 studies (2 RCT) Mixed effect Low quality Insufficient evidence 2 studies (2 RCT) Mixed effect Low to high quality Insufficient evidence No studies 5 studies (5 RCT) Mixed findings Moderate quality Some evidence of positive effect 3 studies (3 RCT) Mixed findings Low to high quality Inconsistent evidence 2 studies (2 RCT) Mixed effect Very low to moderate quality Insufficient evidence No studies

sclerosis Sleep No studies 2 studies (1 RCT) Mixed effect (mostly positive) Moderate to high quality Insufficient evidence 3 studies (2 RCT) Mixed effect Very low to low quality Insufficient evidence 1 study (1 RCT) Positive effect Moderate quality Insufficient evidence 4 studies (3 RCT) Mostly positive effect Low to high quality Some evidence of effect No studies 1 study (1 RCT) Positive effect Low quality Insufficient evidence

multiple

of Ataxia and tremor No studies 3 studies (2 RCT) No change Very low to high quality Unlikely to have an effect No studies 2 studies (2 RCT) No change Moderate quality Unlikely to have an effect 4 studies (4 RCT) No change Low to high quality Unlikely to have an effect 1 study (1 RCT) No change Low quality Insufficient evidence No studies
treatment

the reports
in Bladder function 2 studies (1 RCT) Inconsistent evidence 1 study (No RCT) Positive effect Very low quality Insufficient evidence 2 studies (2 RCT) Moderate quality Insufficient evidence 4 studies (2 RCT) Mixed findings Very low to high Inconsistent evidence 1 study (1 RCT) Positive effect Very low quality Insufficient evidence series/case
cannabinoids No studies Mixed effect High quality Mixed effect quality No studies case

and or
cannabis Spasticity 2 studies (2 RCT) Positive effect Low quality Insufficient evidence 5 studies (5 RCT) Mixed effect Low to high quality Inconsistent evidence 2 studies (1 RCT) Positive effect Very low to low quality Insufficient evidence 7 studies (6 RCT) Mixed effect Very low to moderate quality Inconsistent evidence 6 studies (5 RCT) Mixed findings Low to high quality Inconsistent evidence 2 studies (2 RCT) Positive effect Very l

of studies observational
efficacy V5.1) studies

and Very low to moderate quality studies observational
safety 1 study (1 RCT) Insufficient evidence 4 studies (3 RCT) Low to high quality Some evidence of positive 3 studies (2 RCT) Very low to low Some evidence of effect 8 studies (5 RCT) Inconsistent evidence 7 studies (5 RCT) Very low to high quality Inconsistent evidence 1 study (1 RCT) Insufficient evidence 2 studies (2 RCT) Insufficient evidence Handbook observational downgraded
the Positive effect Low quality Positive effect effect Positive effect Mixed effect Mixed findings Positive effect Very low Mixed effect Low quality observational upgraded or
on Pain Cochrane or or trials;
evidence in trials; trials;

level disease progression 1 study (1 RCT) Insufficient evidence 4 studies (2 RCT) No change/negative effect Very low to high Inconsistent evidence 2 studies (2 RCT) Moderate quality Insufficient evidence 6 studies (5 RCT) Low to high quality Inconsistent evidence approach double-upgraded randomised randomised randomised
study Disability and No change Low quality No studies No change Mixed effect No studies No studies or

of GRADE trials; triple-downgraded
Summary (Per randomised downgraded double-downgraded

2 Cannabis sativa (smoked) Findings Quality of evidence Conclusion Findings Quality of evidence Conclusion THC extract Findings Quality of evidence Conclusion Findings Quality of evidence Conclusion THC:CBD extracts Findings Quality of evidence Conclusion Findings Quality of evidence Conclusion CBD extract Findings Quality of evidence Conclusion rating Moderate, low,
Table Dronabinol Nabiximols Nabilone Quality High, Low, Very